Sib-parentage testing using molecular markers when parents are unknown

Anim Genet. 2002 Oct;33(5):364-71. doi: 10.1046/j.1365-2052.2002.00882.x.

Abstract

The formulae for computing the so-called Sib Index using codominant alleles for (1) full-sib and (2) half-sib parentage are given. Hypothesis testing is based on the distribution of conditional likelihood ratio or Bayes' factor. Thresholds for rejecting the null hypothesis and P-values were obtained in function of the number of alleles and their frequency distributions. Simulations showed that a relatively low number of marker systems (e.g. 20) are enough to accept the hypothesis of sib parentage with a reasonable power for usual significance levels, but that a higher number would be necessary if full-sib against half-sib parentage is the contrast to be carried out. The effect of sampling variation on the allele frequencies on power calculations is also analysed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Animals
  • Breeding*
  • Dogs / genetics
  • Female
  • Genetic Markers
  • Genotype
  • Likelihood Functions
  • Male
  • Models, Genetic*

Substances

  • Genetic Markers