Synthesis and NMR structure of peptidomimetic alpha4beta7-integrin antagonists

Chembiochem. 2002 Jun 3;3(6):575-8. doi: 10.1002/1439-7633(20020603)3:6<575::AID-CBIC575>3.0.CO;2-7.
No abstract available

MeSH terms

  • Amides / chemistry
  • Amides / pharmacology
  • Aza Compounds / chemistry
  • Aza Compounds / pharmacology
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / pharmacology
  • Cell Adhesion / drug effects
  • Drug Design
  • Humans
  • Inhibitory Concentration 50
  • Integrins / antagonists & inhibitors*
  • Integrins / chemistry*
  • Intercellular Adhesion Molecule-1 / metabolism
  • Jurkat Cells / drug effects
  • Lymphocytes / drug effects
  • Models, Molecular
  • Molecular Conformation
  • Mucoproteins / metabolism
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / pharmacology
  • Vascular Cell Adhesion Molecule-1 / metabolism

Substances

  • Amides
  • Aza Compounds
  • Integrins
  • Mucoproteins
  • Peptides, Cyclic
  • Vascular Cell Adhesion Molecule-1
  • integrin alpha4beta7
  • Intercellular Adhesion Molecule-1