Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine

T L Li; O W Choroba; H Hong; D H Williams; J B Spencer

doi:10.1039/b106638b

Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine

Chem Commun (Camb). 2001 Oct 21:(20):2156-7. doi: 10.1039/b106638b.

Authors

T L Li¹, O W Choroba, H Hong, D H Williams, J B Spencer

Affiliation

¹ Cambridge Centre for Molecular Recognition, Department of Chemistry, Cambridge University, Lensfield Road, Cambridge, UK CB2 1EW.

PMID: 12240210
DOI: 10.1039/b106638b

Abstract

3,5-dihydroxyphenylacetate, a precursor for the non-proteinogenic amino acid 3,5-dihydroxyphenylglycine occurring in glycopeptide antibiotics, is determined to be catalysed by a type III polyketide synthase using malonyl-CoA as a starter unit.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinomycetales / genetics
Actinomycetales / metabolism
Chromatography, Gas
Gene Expression Regulation, Bacterial
Genes, Bacterial
Glycine / analogs & derivatives*
Glycine / biosynthesis*
Glycine / chemistry
Mass Spectrometry
Molecular Structure
Multienzyme Complexes / chemistry*
Multienzyme Complexes / classification
Multienzyme Complexes / genetics
Multienzyme Complexes / metabolism*
Polymerase Chain Reaction
Resorcinols / chemistry
Sequence Homology, Amino Acid
Vancomycin / analogs & derivatives*
Vancomycin / biosynthesis*
Vancomycin / chemistry

Substances

Multienzyme Complexes
Resorcinols
3,5-dihydroxyphenylglycine
Vancomycin
Glycine