Abstract
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antigen-Presenting Cells / enzymology
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Antigen-Presenting Cells / immunology
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Antigens, CD / analysis
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Cell Adhesion
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Cell Lineage
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Cells, Cultured
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Dendritic Cells / enzymology*
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Dendritic Cells / immunology*
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Down-Regulation
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Enzyme Inhibitors / pharmacology
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Humans
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Interferon-gamma / pharmacology
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Interleukin-10 / pharmacology
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Interleukin-3 Receptor alpha Subunit
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Lymphocyte Activation
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Lymphocyte Culture Test, Mixed
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Lymphoid Tissue / cytology
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Lymphoid Tissue / enzymology
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Macrophages / enzymology
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Receptors, CCR6
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Receptors, Chemokine / analysis
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Receptors, Interleukin-3 / analysis
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T-Lymphocytes / immunology*
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Tryptophan / analogs & derivatives*
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Tryptophan / pharmacology
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Tryptophan Oxygenase / antagonists & inhibitors
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Tryptophan Oxygenase / metabolism*
Substances
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Antigens, CD
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CCR6 protein, human
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Enzyme Inhibitors
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IL3RA protein, human
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Interleukin-3 Receptor alpha Subunit
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Receptors, CCR6
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Receptors, Chemokine
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Receptors, Interleukin-3
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Interleukin-10
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Interferon-gamma
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Tryptophan
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Tryptophan Oxygenase