Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice

Biosci Biotechnol Biochem. 2002 Jul;66(7):1610-4. doi: 10.1271/bbb.66.1610.

Abstract

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales / chemistry*
  • Agaricus / chemistry*
  • Animals
  • Body Weight / drug effects
  • Cytochrome P-450 CYP1A1 / antagonists & inhibitors
  • Cytochrome P-450 CYP1A1 / biosynthesis
  • Cytochrome P-450 CYP1A1 / genetics
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytochrome P-450 Enzyme System / biosynthesis*
  • Female
  • Gene Expression Regulation, Enzymologic / drug effects
  • Lentinan / pharmacology
  • Lentinula / chemistry*
  • Methylcholanthrene / pharmacology
  • Mice
  • Mice, Inbred BALB C
  • Organ Size / drug effects
  • Polysaccharides / pharmacology*

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Polysaccharides
  • Lentinan
  • Methylcholanthrene
  • Cytochrome P-450 Enzyme System
  • Cytochrome P-450 CYP1A1