Abstract
The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases. Although originally identified as a myeloid-differentiation marker, MyD88 is now known to play an essential role in the innate immune response of insects and mammals. The generation of MyD88-deficient mice, as well as the identification of MyD88-related proteins and regulators of MyD88 signaling, has revealed new and important insights into the function of MyD88.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Amino Acid Sequence
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Animals
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Antigens, Differentiation / genetics
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Antigens, Differentiation / immunology
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Antigens, Differentiation / physiology*
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Bacterial Outer Membrane Proteins / immunology
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Bacterial Outer Membrane Proteins / physiology*
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Humans
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Molecular Sequence Data
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Myeloid Differentiation Factor 88
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Receptors, Immunologic / antagonists & inhibitors
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Receptors, Immunologic / genetics
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Receptors, Immunologic / immunology
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Receptors, Immunologic / physiology*
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Receptors, Interleukin-1 / metabolism
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Receptors, Interleukin-1 / physiology*
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Sequence Homology, Amino Acid
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Signal Transduction
Substances
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Adaptor Proteins, Signal Transducing
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Antigens, Differentiation
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Bacterial Outer Membrane Proteins
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MYD88 protein, human
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Myeloid Differentiation Factor 88
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Receptors, Immunologic
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Receptors, Interleukin-1
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TLR protein, bacteria