Abstract
Some benzimidazolyl sulphones were synthesized and evaluated for their antiviral and antiproliferative properties. Compound 10 displayed significant and selective activity against human cytomegalovirus (CMV), compound 14 showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives. Some structure-activity relationships are discussed.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Benzimidazoles / chemical synthesis*
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Benzimidazoles / pharmacology*
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Cytomegalovirus / drug effects
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Drug Screening Assays, Antitumor
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Herpesvirus 3, Human / drug effects
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Humans
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Mice
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Structure-Activity Relationship
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T-Lymphocytes / drug effects
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Tumor Cells, Cultured
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Viral Plaque Assay
Substances
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Antineoplastic Agents
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Antiviral Agents
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Benzimidazoles