Inhibitory activity of diacylglycerol acyltransferase by tanshinones from the root of Salvia miltiorrhiza

Arch Pharm Res. 2002 Aug;25(4):446-8. doi: 10.1007/BF02976599.

Abstract

The inhibitory activity of tanshinones from Salvia miltiorrhiza was tested on rat liver diacylglycerol acyltransferase (DGAT). Cryptotanshinone (1) and 15,16-dihydrotanshinone I (3) exhibited potent DGAT inhibitory activities dose-dependently with IC50 values of 10.5 microg/ml and 11.1 microg/ml. However, tanshinone IIA (2) and tanshinone I (4) showed very weak inhibition (IC50 value: > 250 microg/ml). A dihydrofuran moiety was seemed to be responsible for the stronger inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes
  • Acyltransferases / antagonists & inhibitors*
  • Animals
  • Diacylglycerol O-Acyltransferase
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • In Vitro Techniques
  • Liver / drug effects
  • Liver / enzymology
  • Male
  • Phenanthrenes / chemistry*
  • Phenanthrenes / isolation & purification
  • Phenanthrenes / pharmacology*
  • Plant Roots / chemistry
  • Rats
  • Rats, Sprague-Dawley
  • Salvia / chemistry*
  • Taiwan

Substances

  • Abietanes
  • Enzyme Inhibitors
  • Phenanthrenes
  • tanshinone
  • Acyltransferases
  • Diacylglycerol O-Acyltransferase