Influence of structure and chirality of the selector on the chiral recognition of amino acids using ligand-exchange capillary electrophoresis

Electrophoresis. 2002 Sep;23(17):3006-12. doi: 10.1002/1522-2683(200209)23:17<3006::AID-ELPS3006>3.0.CO;2-4.

Abstract

The dependence of the chiral recognition ability and enantiomer migration order on the structure, substitution pattern and chirality of chiral selectors used in ligand-exchange capillary electrophoresis is investigated. As chiral selectors different N-alkyl derivatives of proline and hydroxyproline as their copper(II) complexes are used. The influence of the position and conformation of the hydroxy group in the hydroxyproline derivatives and of the structure and chirality of the side chain on enantioselectivity is investigated. Furthermore, the effect of surfactants such as sodium dodecyl sulfate and cetyl trimethyl ammonium bromide on resolution and enantiomer migration order is studied. The investigations were carried out with three aromatic amino acids as model compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / isolation & purification*
  • Copper / chemistry
  • Electrophoresis, Capillary / methods*
  • Hydroxyproline / chemistry
  • Hydroxyproline / isolation & purification
  • Ligands
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / isolation & purification
  • Proline / chemistry
  • Proline / isolation & purification
  • Stereoisomerism
  • Surface-Active Agents

Substances

  • Amino Acids
  • Ligands
  • Organometallic Compounds
  • Surface-Active Agents
  • Copper
  • Proline
  • Hydroxyproline