Abstract
Objective:
Investigating the effect of GLB7 on cAMP in murine peritoneal macrophages to provide a scientific evidence for the immunomodulatory mechanism.
Method:
Cell culture and radio-immunological assay of cAMP were used.
Result:
GLB7 increased the production of cAMP in a concentration and time dependent manner in murine peritoneal macrophages.
Conclusion:
The immunopotentiating effect of GLB7 may be due to the activation of macrophages that leads to the increase of cAMP.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / isolation & purification
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Adjuvants, Immunologic / pharmacology*
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Animals
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Cells, Cultured
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Cyclic AMP / metabolism
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Female
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Macrophages, Peritoneal / cytology
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Macrophages, Peritoneal / metabolism*
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Male
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Mice
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Mice, Inbred BALB C
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Plants, Medicinal / chemistry
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Polysaccharides / isolation & purification
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Polysaccharides / pharmacology*
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Reishi / chemistry*
Substances
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Adjuvants, Immunologic
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Polysaccharides
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Cyclic AMP