To investigate the relationship between porins deficiency and the resistance of Escherichia coli HX88108. The porins of Escherichia coli HX88108 were studied by SDS-PAGE and were compared with the porins of standard strains. The result showed that E. coli HX88108 did not lose OmpF and OmpC, and the molecular weights of these two porins were 38 kd and 37 kd respectively. There is no relationship between the resistance of Escherichia coli HX88108 and porins deficiency.