Two new molecular PML-RARalpha variants: implications for the molecular diagnosis of APL

Haematologica. 2002 Aug;87(8):ELT37.

Authors

José Luis Vizmanos¹, María José Larrráyoz, María Dolores Odero, Ramón Lasa, Marcos González, Francisco Javier Novo, María José Calasanz

Affiliation

¹ Department of Genetics, School of Science, University of Navarre, C/Irunlarrea s/n E-31080 Pamplona, Navarre, Spain. jlvizmanos@unav.es

PMID: 12161382

No abstract available

Publication types

Case Reports

MeSH terms

Aged
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Chromosome Breakage
Chromosomes, Human, Pair 15 / genetics*
Chromosomes, Human, Pair 15 / ultrastructure
Chromosomes, Human, Pair 17 / genetics*
Chromosomes, Human, Pair 17 / ultrastructure
Computer Systems
DNA Mutational Analysis
DNA Primers
Exons / genetics
False Negative Reactions
Humans
Introns / genetics
Karyotyping
Leukemia, Promyelocytic, Acute / diagnosis*
Leukemia, Promyelocytic, Acute / genetics
Male
Middle Aged
Neoplasm Proteins / genetics*
Oncogene Proteins, Fusion / genetics*
Protein Isoforms / genetics
RNA, Messenger / genetics
RNA, Neoplasm / genetics
Remission Induction
Reverse Transcriptase Polymerase Chain Reaction*
Translocation, Genetic / genetics*

Substances

DNA Primers
Neoplasm Proteins
Oncogene Proteins, Fusion
Protein Isoforms
RNA, Messenger
RNA, Neoplasm
promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein