12 patients with cancer arising from a cirrhosis of the liver and 8 patients with regenerative nodes in a cirrhotic liver have been examined with scintigraphy, serial scintigraphy, angiography and biopsy. The results show that defects in the parenchyma of the liver can be shown with relative certainty using conventional scintigraphy with radiocolloids. But nothing can be said about their nature. Because of the simplicity of this technique and the minor claims on the patient scintigraphy should be the first diagnostic step. If angiography is contra-indicated serial scintigraphy may further elucidate the effects. When, however, angiography can be done, it will offer the best chance of differentiating between cancer and regenerative nodes on the basis of cirrhosis.