Abstract
Genetic factors including alpha(1)-antitrypsin deficiency are important in COPD. Candidate gene association studies in COPD are reviewed. Efforts to identify interactions between genetic factors and environmental determinants such as smoking may lead to improved understanding of the pathogenesis of the disease.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Antioxidants / metabolism
-
Endopeptidases / genetics
-
Forced Expiratory Volume / physiology
-
Genetic Linkage
-
Genetic Predisposition to Disease
-
Genotype
-
Glutathione Transferase / genetics
-
Humans
-
Mutation / genetics
-
Pulmonary Disease, Chronic Obstructive / genetics*
-
Smoking / genetics
-
Vital Capacity / physiology
-
alpha 1-Antitrypsin Deficiency / genetics
Substances
-
Antioxidants
-
Glutathione Transferase
-
Endopeptidases