Abstract
The aerial parts of Inula verbascifolia subsp. methanea yielded three new epoxygermacranolides, compounds 1-3, in addition to the previously known 9beta-hydroxyparthenolide. The structures of 1-3 have been elucidated on the basis of their spectral data (MS, CD, 1D and 2D NMR) and by quantum mechanical calculations. The in vitro cytotoxic activity of compounds 1-3 was evaluated against six human solid tumor cell lines.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Breast Neoplasms
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Chromatography, Thin Layer
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Circular Dichroism
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Colonic Neoplasms
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Drug Screening Assays, Antitumor
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Female
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Greece
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Humans
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Inula / chemistry*
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Male
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Mass Spectrometry
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Prostatic Neoplasms
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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9-(3-hydroxy-2-methylbutyryloxy)parthenolide
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9-(3-hydroxy-3-methylpentanoyloxy)parthenolide
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9-(3-hydroxyisovaleryloxy)parthenolide
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes