Carvone and perillaldehyde interfere with the serum-induced formation of filamentous structures in Candida albicans at substantially lower concentrations than those causing significant inhibition of growth

J Nat Prod. 2002 Jul;65(7):953-5. doi: 10.1021/np010621l.

Abstract

Carvone and perillaldehyde were shown to inhibit the transformation of Candida albicans to a filamentous form at concentrations far lower and more biologically relevant than the concentrations necessary to inhibit growth. This morphological transformation is associated with C. albicans pathogenicity; hence these naturally occurring monoterpenes are potential lead compounds in the development of therapeutic agents against C. albicans infection.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Blood
  • Candida albicans* / cytology
  • Candida albicans* / drug effects
  • Candida albicans* / pathogenicity
  • Cyclohexane Monoterpenes
  • Dose-Response Relationship, Drug
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Monoterpenes*
  • Stereoisomerism
  • Terpenes / chemistry
  • Terpenes / pharmacology*

Substances

  • Antifungal Agents
  • Cyclohexane Monoterpenes
  • Monoterpenes
  • Terpenes
  • perillaldehyde
  • carvone