Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2225-8. doi: 10.1016/s0960-894x(02)00348-7.

Abstract

In an attempt to identify novel ligands for the dopamine transporter, a series of 4-substituted-2-phenylquinazolines were synthesized and evaluated. Among the compounds studied, 4-[(diphenylmethyl)amino]-2-phenylquinazoline (4 g) was identified as a novel partial inhibitor of [(125)I]RTI-55 binding to the dopamine transporter and a partial inhibitor of [(3)H]dopamine uptake.

MeSH terms

  • Biological Transport / drug effects
  • Cocaine / analogs & derivatives*
  • Cocaine / antagonists & inhibitors
  • Cocaine / metabolism
  • Dopamine / metabolism
  • Dopamine Plasma Membrane Transport Proteins
  • Dopamine Uptake Inhibitors / chemical synthesis
  • Dopamine Uptake Inhibitors / chemistry*
  • Dopamine Uptake Inhibitors / pharmacology*
  • Membrane Glycoproteins*
  • Membrane Transport Modulators*
  • Membrane Transport Proteins / antagonists & inhibitors*
  • Membrane Transport Proteins / metabolism
  • Molecular Structure
  • Nerve Tissue Proteins*
  • Protein Binding
  • Quinazolines / chemical synthesis
  • Quinazolines / chemistry*
  • Quinazolines / pharmacology*
  • Structure-Activity Relationship

Substances

  • 4-((Diphenylmethyl)amino)-2-phenylquinazoline
  • Dopamine Plasma Membrane Transport Proteins
  • Dopamine Uptake Inhibitors
  • Membrane Glycoproteins
  • Membrane Transport Modulators
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Quinazolines
  • 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane
  • Cocaine
  • Dopamine