Abstract
A novel series of antimicrobials of the oxazolidinone class is disclosed. These compounds are characterized relative to previously described analogues by a 'halostilbene-derived' pharmacophore and demonstrate enhanced antimicrobial activity against key Gram-positive pathogens when compared to Linezolid.
MeSH terms
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Acetamides / pharmacology
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Gram-Positive Bacteria / drug effects
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Linezolid
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Molecular Structure
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Oxazolidinones / chemical synthesis*
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Oxazolidinones / chemistry
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Oxazolidinones / pharmacology*
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Rats
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Structure-Activity Relationship
Substances
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Acetamides
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Anti-Bacterial Agents
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Oxazolidinones
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Linezolid