Abstract
The immune response against early regulatory proteins of simian- and human immunodeficiency virus (SIV, HIV) has been associated with a milder course of infection. Here, we directly compared vaccination with Tat/Rev versus Pol/Gag. Challenge infection with SIVmac32H (pJ5) suggested that vaccination with Tat/Rev induced cellular immune responses that enabled cynomolgus macaques to more efficiently control SIV replication than the vaccine-induced immune responses against Pol/Gag. Vaccination with Tat/Rev resulted in reduced plasma SIV loads compared with control (P=0.058) or Pol/Gag-vaccinated (P=0.089) animals, with undetectable plasma viral loads in two of the four Tat/Rev-vaccinated animals. Therefore, the results warrant further investigation of the early regulatory proteins and their potential for vaccination against HIV.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antibodies, Viral / biosynthesis
-
Antibodies, Viral / blood
-
Base Sequence
-
Gene Products, gag / genetics
-
Gene Products, gag / immunology
-
Gene Products, pol / genetics
-
Gene Products, pol / immunology
-
Gene Products, rev / genetics
-
Gene Products, rev / immunology
-
Gene Products, tat / genetics
-
Gene Products, tat / immunology
-
Humans
-
Immunity, Cellular
-
Macaca fascicularis
-
RNA, Viral / blood
-
RNA, Viral / genetics
-
SAIDS Vaccines / genetics
-
SAIDS Vaccines / immunology*
-
Simian Acquired Immunodeficiency Syndrome / immunology
-
Simian Acquired Immunodeficiency Syndrome / prevention & control
-
Simian Acquired Immunodeficiency Syndrome / virology
-
Simian Immunodeficiency Virus / genetics
-
Simian Immunodeficiency Virus / immunology*
-
Viremia / immunology
-
Viremia / prevention & control
-
Viremia / virology
Substances
-
Antibodies, Viral
-
Gene Products, gag
-
Gene Products, pol
-
Gene Products, rev
-
Gene Products, tat
-
RNA, Viral
-
SAIDS Vaccines