Kottamides A-D: novel bioactive imidazolone-containing alkaloids from the New Zealand ascidian Pycnoclavella kottae

J Org Chem. 2002 Jul 26;67(15):5402-4. doi: 10.1021/jo0201427.

Abstract

Kottamides A-D (1-4), novel 2,2,5-trisubstituted imidazolone-containing alkaloids, were isolated from the New Zealand endemic ascidian Pycnoclavella kottae and structurally characterized using 15N natural abundance 2-D NMR in addition to standard spectroscopic methods. The kottamides exhibited anti-inflammatory and anti-metabolic activity as well as cytotoxicity toward tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Amino Acid Sequence
  • Animals
  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification*
  • Anti-Infective Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Bacillus subtilis / drug effects
  • Candida albicans / drug effects
  • Drug Screening Assays, Antitumor
  • Escherichia coli / drug effects
  • Indazoles / chemistry
  • Indazoles / isolation & purification*
  • Indazoles / pharmacology
  • Inhibitory Concentration 50
  • Leukemia
  • Leukemia P388
  • Mice
  • Molecular Structure
  • New Zealand
  • Nuclear Magnetic Resonance, Biomolecular
  • Stereoisomerism
  • Trichophyton / drug effects
  • Tumor Cells, Cultured / drug effects
  • Urochordata / chemistry*

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Antineoplastic Agents
  • Antiviral Agents
  • Indazoles