Isolation of a new mycalolide from the marine sponge Mycale izuensis

J Nat Prod. 2002 Jun;65(6):942-3. doi: 10.1021/np010663+.

Abstract

Bioassay-directed fractionation of the lipophilic extract of the marine sponge Mycale izuensis led to the isolation of cytotoxic mycalolides including a new compound, 30,32-dihydroxymycalolide A (1). Its structure including absolute stereochemistry was deduced by spectroscopic and chemical methods. Compound 1 was cytotoxic against HeLa cells with an IC(50) value of 2.6 ng/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Chromatography, High Pressure Liquid
  • Drug Screening Assays, Antitumor
  • Female
  • HeLa Cells / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Japan
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oxazoles / chemistry
  • Oxazoles / isolation & purification*
  • Oxazoles / pharmacology
  • Porifera / chemistry*
  • Tumor Cells, Cultured / drug effects
  • Uterine Cervical Neoplasms

Substances

  • 30,32-dihydroxymycalolide A
  • Antineoplastic Agents
  • Oxazoles