Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model

N J Brown; C A Staton; G R Rodgers; K P Corke; J C E Underwood; C E Lewis

doi:10.1038/sj.bjc.6600320

Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model

Br J Cancer. 2002 Jun 5;86(11):1813-6. doi: 10.1038/sj.bjc.6600320.

Authors

N J Brown¹, C A Staton, G R Rodgers, K P Corke, J C E Underwood, C E Lewis

Affiliation

¹ Microcirculation Research Unit, University of Sheffield Medical School, Sheffield S10 2RX, UK.

Abstract

We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / blood supply
Adenocarcinoma / etiology
Adenocarcinoma / pathology*
Animals
Cell Differentiation / drug effects
Cell Division / drug effects
Colonic Neoplasms / blood supply
Colonic Neoplasms / drug therapy
Colonic Neoplasms / pathology*
Disease Models, Animal
Endothelium, Vascular / cytology
Endothelium, Vascular / drug effects
Fibrin Fibrinogen Degradation Products / pharmacology*
Humans
Mice
Mice, Inbred BALB C
Neovascularization, Pathologic / prevention & control*

Substances

Fibrin Fibrinogen Degradation Products
fibrinogen fragment E