Objective: We observed the changes in both serum lipoprotein(a) [Lp(a)] and plasma endothelin (ET) during upper abdominal surgery under intravenous combined with inhalation anesthesia and we also analyzed their correlativity.
Methods: Fifteen patients, scheduled for upper abdominal surgery, were anesthetized with total does of fentanal 8-12 micrograms.kg-1 and inhalation of 1-2 MAC enflurane. Serum Lp(a) and plasma ET at pre-anesthesia, pre-operation, 1 h from the start of operation and 30 min after operation were determined.
Results: The average concentrations of Lp(a) and ET were increased at 1 h from the start of operation compared with pre-anesthesia, but had no statistical significance. Lp(a) and ET were significantly higher at 30 min after operation than pre-anesthesia(P < 0.05).
Conclusion: Lp(a) and ET have a close relation in advancing cardio-cerebral blood vessel diseases.