Abstract
We report in vitro antimalarial activities against chloroquine sensitive and resistant Plasmodium falciparum strains, and in vivo activities against Plasmodium berghei in mice for four series of ring-substituted-L-histidines and histamines.
MeSH terms
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / pharmacology*
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Chloroquine / pharmacology
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Drug Resistance
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Histamine / analogs & derivatives*
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Histamine / chemical synthesis
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Histamine / pharmacology
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Histidine / analogs & derivatives*
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Histidine / chemical synthesis
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Histidine / chemistry
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Histidine / pharmacology
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Imidazoles / chemical synthesis*
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Imidazoles / chemistry
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Imidazoles / pharmacology*
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In Vitro Techniques
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Inhibitory Concentration 50
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Mice
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Plasmodium berghei / drug effects
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Plasmodium falciparum / drug effects
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Structure-Activity Relationship
Substances
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Antimalarials
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Imidazoles
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Histidine
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2-fluorohistidine
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imidazole
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Histamine
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Chloroquine