2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a novel antioxidant, from Penicillium citrinum F5

J Nat Prod. 2002 May;65(5):740-1. doi: 10.1021/np010605o.

Abstract

Bioassy-directed fractionation of a culture broth of Penicillium citrinum F5 led to the isolation of a novel antioxidant 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran (1), together with gentisic acid (2), and their structures were determined on the basis of spectroscopic data. In the 1,1-diphenyl-picryl-hydrazyl (DPPH) assay system, compounds 1 and 2 showed free radical scavenging activity with IC(20) values of 10.39 and 4.26 microM, respectively.

Publication types

  • Comparative Study

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification*
  • Benzofurans / pharmacology
  • Biphenyl Compounds
  • Chromatography, High Pressure Liquid
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / isolation & purification*
  • Free Radical Scavengers / pharmacology
  • Inhibitory Concentration 50
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Penicillium / chemistry*
  • Picrates
  • Taiwan

Substances

  • 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran
  • Antioxidants
  • Benzofurans
  • Biphenyl Compounds
  • Free Radical Scavengers
  • Picrates
  • 1,1-diphenyl-2-picrylhydrazyl