Preparation and reactions of 2-chloro-3,4-epoxy-1-butene: a convenient route to (Z)-3-chloroallylic alcohols

J Org Chem. 2002 May 31;67(11):3847-51. doi: 10.1021/jo020079l.

Abstract

Epoxide 2 was prepared from 3,4-dichloro-1-butene (1) by epoxidation with m-CPBA and subsequent dehydrohalogenation of the intermediate dichloroepoxide with molten KOH, affording 2 in 64% overall yield (2 steps). Catalytic CuBr/SMe(2)-mediated S(N)2' addition of sp(2)- or sp(3)-hybridized Grignard reagents to 2-chloro-3,4-epoxy-1-butene (2) afforded (Z)-3-chloroallylic alcohols such as 3 in good yields and with high regio- and stereoselectivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohols / chemical synthesis*
  • Butanes / chemical synthesis
  • Butanes / chemistry*
  • Epoxy Compounds / chemical synthesis
  • Epoxy Compounds / chemistry*
  • Hydrocarbons, Chlorinated / chemical synthesis*

Substances

  • 2-chloro-3,4-epoxy-1-butene
  • Alcohols
  • Butanes
  • Epoxy Compounds
  • Hydrocarbons, Chlorinated