Dugbe nairovirus S segment: correction of published sequence and comparison of five isolates

Virology. 2002 Mar 15;294(2):364-71. doi: 10.1006/viro.2001.1324.

Abstract

The sequence of the S (small) RNA segment of the ArD 44313 isolate of Dugbe nairovirus (DUG) has been redetermined, and a number of apparent errors in the previously reported sequence (V. K. Ward, A. C. Marriott, A. A. El-Ghorr, and P. A. Nuttall, 1990, Virology 175, 518-524) were revealed. Our results indicate that the S RNA is 1716 nucleotides (nt) in length and contains one large open reading frame spanning 1449 nt. This can encode a 483 amino acid polypeptide, M(r) 53.9 kDa, corresponding to the viral nucleocapsid protein N. The DUG N protein is thus similar in length to the N proteins of Hazara (HAZ) and Crimean-Congo haemorrhagic fever (CCHF) nairoviruses, which are 485 and 482 amino acids in length, respectively. S segment RNA sequences were also determined for DUG isolates IbAr 1792, IbH 11480, ArD 16095, and KT 281/75; only the KT 281/75 sequence differed markedly from that of ArD 44313. Phylogenetic trees were constructed for these nairovirus S segment sequences.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Cricetinae
  • DNA, Viral
  • Mice
  • Molecular Sequence Data
  • Nairovirus / classification
  • Nairovirus / genetics*
  • Nairovirus / isolation & purification
  • Phylogeny
  • RNA, Viral / analysis*
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid

Substances

  • DNA, Viral
  • RNA, Viral

Associated data

  • GENBANK/AF434161
  • GENBANK/AF434162
  • GENBANK/AF434163
  • GENBANK/AF434164
  • GENBANK/AF434165