Abstract
Memory is sensitive to the short-acting anesthetic (2,6-diisopropylphenol) propofol, but the underlying mechanism is little known. Here, we have examined the effects of propofol on synaptic plasticity in the CA1 region of the hippocampus of anesthetized rats. We found that low dose of propofol (20 mg/kg, i.p.) did not affect the basal transmission, but enhanced prominently the development of long-term depression (LTD) and impaired the maintenance of long-term potentiation (LTP). The impairment of LTP maintenance and enhancement of LTD development may contribute to propofol-induced deficits in memory following propofol anesthesia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2-Amino-5-phosphonovalerate / pharmacology
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Anesthetics, Intravenous / pharmacology*
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Animals
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Dose-Response Relationship, Drug
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Electric Stimulation
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Excitatory Amino Acid Antagonists / pharmacology
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Hippocampus / drug effects*
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Hippocampus / physiology
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Long-Term Potentiation / drug effects*
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Long-Term Potentiation / physiology
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Male
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Memory / drug effects
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Memory / physiology
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Memory Disorders / chemically induced*
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Memory Disorders / metabolism
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Memory Disorders / physiopathology
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Neural Inhibition / drug effects*
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Neural Inhibition / physiology
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Presynaptic Terminals / drug effects*
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Presynaptic Terminals / metabolism
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Propofol / pharmacology*
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Rats
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Rats, Wistar
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Receptors, GABA-A / drug effects
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Receptors, GABA-A / metabolism
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Receptors, N-Methyl-D-Aspartate / drug effects
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Receptors, N-Methyl-D-Aspartate / metabolism
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
Substances
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Anesthetics, Intravenous
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Excitatory Amino Acid Antagonists
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Receptors, GABA-A
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Receptors, N-Methyl-D-Aspartate
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2-Amino-5-phosphonovalerate
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Propofol