Abstract
A new structure reveals how substrates are recognized for conjugation to the ubiquitin-like protein SUMO, a posttranslational modification that functions in activation of transcription factors, nuclear import, and cell division.
MeSH terms
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Binding Sites
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GTPase-Activating Proteins / chemistry*
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GTPase-Activating Proteins / metabolism
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Ligases / chemistry*
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Ligases / metabolism
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Models, Molecular
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Protein Conformation
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Protein Structure, Tertiary*
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SUMO-1 Protein / chemistry*
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SUMO-1 Protein / metabolism
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Ubiquitin / metabolism
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Ubiquitin-Conjugating Enzyme UBC9
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Ubiquitin-Conjugating Enzymes*
Substances
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GTPase-Activating Proteins
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SUMO-1 Protein
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Ubiquitin
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Ubiquitin-Conjugating Enzymes
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Ligases
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Ubiquitin-Conjugating Enzyme UBC9