Retro-translocation of proteins from the endoplasmic reticulum into the cytosol

Nat Rev Mol Cell Biol. 2002 Apr;3(4):246-55. doi: 10.1038/nrm780.

Abstract

Proteins that are misfolded in the endoplasmic reticulum are transported back into the cytosol for destruction by the proteasome. This retro-translocation pathway has been co-opted by certain viruses, and by plant and bacterial toxins. The mechanism of retro-translocation is still mysterious, but several aspects of this process are now being unravelled.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adenosine Triphosphatases / metabolism
  • Animals
  • Biological Transport, Active
  • Cholera Toxin / chemistry
  • Cholera Toxin / metabolism
  • Cysteine Endopeptidases / metabolism
  • Cytosol / metabolism*
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Models, Biological
  • Multienzyme Complexes / metabolism
  • Proteasome Endopeptidase Complex
  • Protein Folding
  • Proteins / chemistry
  • Proteins / metabolism*
  • Ubiquitin / metabolism

Substances

  • Multienzyme Complexes
  • Proteins
  • Ubiquitin
  • Cholera Toxin
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex
  • Adenosine Triphosphatases