Isolation, structure elucidation, and absolute configuration of 26-deoxyactein from Cimicifuga racemosa and clarification of nomenclature associated with 27-deoxyactein

J Nat Prod. 2002 Apr;65(4):601-5. doi: 10.1021/np010494t.

Abstract

A new triterpene glycoside, 26-deoxyactein (1), along with two known compounds, 23-epi-26-deoxyactein (2), previously designated as "27-deoxyactein", and actein (3), were isolated from the roots/rhizomes of Cimicifuga racemosa. The structures and absolute stereochemistry of 1 and 2 were established by spectroscopic methods (FABMS, (1)H and (13)C NMR) and single-crystal X-ray data analysis.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Crystallography, X-Ray
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Ranunculaceae / chemistry*
  • Ranunculaceae / classification
  • Rhizome / chemistry
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Stereoisomerism
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Virginia

Substances

  • Saponins
  • Triterpenes
  • 23-epi-26-deoxyactein
  • 26-deoxyactein