Aryl-aryl coupling reaction using a novel and highly active palladium reagent prepared from Pd(OAc)2, 1,3-bis[diphenylphosphino]propane (DPPP), and Bu3P

Chem Pharm Bull (Tokyo). 2002 Apr;50(4):519-22. doi: 10.1248/cpb.50.519.

Abstract

A palladium-assisted coupling reaction of aryl triflate with arene was investigated, and a novel Pd reagent prepared from equimolar Pd(OAc)2, 1,3-Bis[diphenylphosphino]propane (DPPP), and Bu3P was developed. This method is useful for intramolecular biaryl coupling reactions, not only between aryl triflate and arene (triflate-amide), but also between aryl halide and arene (halo-amide).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclization
  • Hydrocarbons, Aromatic / chemical synthesis*
  • Indicators and Reagents
  • Organometallic Compounds / chemistry*
  • Palladium / chemistry*
  • Phosphines / chemistry*
  • Propane / analogs & derivatives
  • Propane / chemistry*

Substances

  • Hydrocarbons, Aromatic
  • Indicators and Reagents
  • Organometallic Compounds
  • Phosphines
  • tri-n-butylphosphine
  • 1,3-bis(diphenylphosphino)propane
  • Palladium
  • Propane