Abstract
Iodinated 3beta-aryltropanes functionalized appropriately at the 2beta-, 8- and aryl positions display selective binding to either the dopamine or serotonin transporters.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Binding Sites
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Binding, Competitive
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Carrier Proteins / metabolism*
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Dopamine / metabolism
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Dopamine Plasma Membrane Transport Proteins
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Hydrocarbons, Iodinated / chemical synthesis*
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Hydrocarbons, Iodinated / chemistry
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Hydrocarbons, Iodinated / pharmacokinetics
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Iodine Radioisotopes
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Membrane Glycoproteins / metabolism*
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Membrane Transport Proteins / metabolism*
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Nerve Tissue Proteins*
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Radiopharmaceuticals / chemical synthesis
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Serotonin / metabolism
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Serotonin Plasma Membrane Transport Proteins
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Structure-Activity Relationship
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Tropanes / chemical synthesis*
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Tropanes / chemistry
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Tropanes / pharmacokinetics
Substances
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Carrier Proteins
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Dopamine Plasma Membrane Transport Proteins
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Hydrocarbons, Iodinated
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Iodine Radioisotopes
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Radiopharmaceuticals
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Serotonin Plasma Membrane Transport Proteins
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Tropanes
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Serotonin
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Dopamine