Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology

Y Yazici; D Erkan; D M Levine; T S Parker; M D Lockshin

doi:10.1191/0961203302lu152cr

Protein-losing enteropathy in systemic lupus erythematosus: report of a severe, persistent case and review of pathophysiology

Lupus. 2002;11(2):119-23. doi: 10.1191/0961203302lu152cr.

Authors

Y Yazici¹, D Erkan, D M Levine, T S Parker, M D Lockshin

Affiliation

¹ Hospital for Special Surgery, Weill Medical College of Cornell University, New York, USA. yaziciy@hss.edu

PMID: 11958575
DOI: 10.1191/0961203302lu152cr

Abstract

Protein-losing enteropathy (PLE) is a rare manifestation of systemic lupus erythematosus (SLE). We report a severe and resistant case of PLE, discuss pathophysiology and possible role of cytokines in the disease process. We also present a review of the current literature.

Publication types

Case Reports
Review

MeSH terms

Adult
Cyclophosphamide / therapeutic use
Female
Humans
Interleukin-6 / metabolism
Lupus Erythematosus, Systemic / complications*
Lupus Erythematosus, Systemic / drug therapy
Lupus Erythematosus, Systemic / physiopathology
Methylprednisolone / therapeutic use
Protein-Losing Enteropathies / complications*
Protein-Losing Enteropathies / drug therapy
Protein-Losing Enteropathies / physiopathology*
Tumor Necrosis Factor-alpha / metabolism

Substances

Interleukin-6
Tumor Necrosis Factor-alpha
Cyclophosphamide
Methylprednisolone