Long-term survival after gene therapy for a recurrent glioblastoma

Neurology. 2002 Apr 9;58(7):1109-12. doi: 10.1212/wnl.58.7.1109.

Abstract

A patient presenting with a recurrent glioblastoma (GBM) survived 3 years after suicide gene therapy and finally died of a disseminated breast cancer with no indication of tumor recurrence on MRI. Postmortem analysis showed no evidence of recurrence of the GBM, neither near the initial tumor localization nor in any other area of the brain. Such an evolution is unusual in the course of this disease and may suggest in this particular case a cure of the GBM.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Neoplasms / pathology
  • Brain Neoplasms / therapy*
  • Female
  • Genetic Therapy* / methods
  • Genetic Therapy* / statistics & numerical data
  • Glioblastoma / pathology
  • Glioblastoma / therapy*
  • Humans
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / therapy*
  • Survivors* / statistics & numerical data