N-alkylaminoacids and their derivatives interact with melanocortin receptors

Bioorg Med Chem Lett. 2002 Apr 8;12(7):1039-42. doi: 10.1016/s0960-894x(02)00089-6.

Abstract

Thirty four N-alkylaminoacids (Arg, Trp, Nal, Pro, Hyp, L and D) and derivatives were prepared by a process that included reductive alkylation of the amino function. Both solid phase and solution synthesis was used. Title substances displayed binding activity on melanocortin receptors MC(1,3-5) reaching the low micromolar range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Amino Acids / metabolism*
  • Binding, Competitive
  • Cell Line
  • Humans
  • Iodine Radioisotopes
  • Models, Chemical
  • Molecular Structure
  • Oxidation-Reduction
  • Protein Binding
  • Receptor, Melanocortin, Type 3
  • Receptor, Melanocortin, Type 4
  • Receptors, Corticotropin / metabolism*
  • Receptors, Melanocortin

Substances

  • Amino Acids
  • Iodine Radioisotopes
  • Receptor, Melanocortin, Type 3
  • Receptor, Melanocortin, Type 4
  • Receptors, Corticotropin
  • Receptors, Melanocortin
  • melanocortin 5 receptor