Nobiloside, a new neuraminidase inhibitory triterpenoidal saponin from the marine sponge Erylus nobilis

J Nat Prod. 2002 Mar;65(3):411-3. doi: 10.1021/np010480n.

Abstract

A neuraminidase inhibitor, nobiloside (1), was isolated from the marine sponge Erylus nobilis Thiele, 1903. Its structure was determined as a penasterol trisaccharide. The absolute configurations were determined by NMR and chiral GC analysis. It inhibited neuraminidase from the bacterium Clostridium perfringens with an IC50 value of 0.46 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromatography, Gas
  • Chromatography, High Pressure Liquid
  • Clostridium / enzymology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Japan
  • Molecular Conformation
  • Molecular Structure
  • Neuraminidase / antagonists & inhibitors
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Stereoisomerism
  • Sterols / chemistry
  • Sterols / isolation & purification*
  • Sterols / pharmacology
  • Trisaccharides / chemistry
  • Trisaccharides / isolation & purification*
  • Trisaccharides / pharmacology

Substances

  • Enzyme Inhibitors
  • Sterols
  • Trisaccharides
  • nobiloside
  • Neuraminidase