Purpose: To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor.
Methods: A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously.
Results: After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved.
Conclusions: In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.