Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells

Mech Dev. 2002 Apr;113(1):91-4. doi: 10.1016/s0925-4773(02)00002-3.

Abstract

The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes. These results suggest that PGC7 might play an important role in the development of PGCs and oocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Blastocyst / metabolism*
  • Blotting, Northern
  • Blotting, Western
  • Chromosomal Proteins, Non-Histone
  • DNA, Complementary / metabolism
  • Female
  • Gene Expression Regulation, Developmental
  • Germ Cells / metabolism*
  • Immunohistochemistry
  • Male
  • Mice
  • Molecular Sequence Data
  • Oocytes / metabolism
  • Protein Biosynthesis*
  • Proteins / genetics*
  • Time Factors
  • Tissue Distribution

Substances

  • Chromosomal Proteins, Non-Histone
  • DNA, Complementary
  • DPPA3 protein, human
  • Proteins