Development of a virus concentration method and its application to detection of enterovirus and norwalk virus from coastal seawater

Appl Environ Microbiol. 2002 Mar;68(3):1033-9. doi: 10.1128/AEM.68.3.1033-1039.2002.

Abstract

We developed a new procedure for concentration of enteric viruses from water using a negatively charged membrane. Rinsing the membrane with 0.5 mM H(2)SO(4) (pH 3.0) in order to elute cations prior to viral elution with 1 mM NaOH (pH 10.5) promoted poliovirus recovery yields from 33 to 95% when applied to pure water and 38 to 89% when applied to natural seawater from Tokyo Bay, Japan, respectively. This method showed average recovery yields of spiked poliovirus of 62% (n = 8) from 1 liter of artificial seawater. This method showed higher recovery yields (>61%) than that of the conventional method using positively charged membrane (6%) when applied to seawater. This method is also free from beef extract elution, which has an inhibitory effect in the subsequent viral genome detection by reverse transcription-PCR. Naturally occurring Norwalk viruses from 2 liters of Tokyo Bay water in winter and infectious enteroviruses from 2 liters of recreational coastal seawater in summer were detected by using this viral concentration method.

Publication types

  • Evaluation Study

MeSH terms

  • Enterovirus / isolation & purification*
  • Norwalk virus / isolation & purification*
  • Seawater*
  • Virology / methods
  • Water Microbiology*