Abstract
A viral reservoir of human immunodeficiency virus type 1 (HIV-1)-infected, resting CD4(+) T cells persists despite suppression of plasma viremia by combination antiretroviral therapy. In a longitudinal analysis of three patients treated with a five-drug regimen, both R5 and X4 HIV-1 variants persisted in the cellular reservoir for up to 3 years.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / therapeutic use*
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CD4-Positive T-Lymphocytes / virology
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Cell Line
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Coculture Techniques
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Drug Therapy, Combination
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Genetic Variation*
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Giant Cells
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HIV Infections / drug therapy*
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HIV Infections / virology
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HIV-1 / classification
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HIV-1 / genetics
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HIV-1 / physiology*
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Humans
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Molecular Sequence Data
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Reverse Transcriptase Inhibitors / therapeutic use*
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Sequence Analysis, DNA
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Time Factors
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Viral Load
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Viremia / virology
Substances
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Anti-HIV Agents
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Reverse Transcriptase Inhibitors