Abstract
We have synthesized a new series of coumarins and furocoumarins and evaluated their vasorelaxant activity in rat aorta rings pre-contracted with noradrenaline or by depolarisation with high KCl. The new furocoumarins relax smooth vascular muscle with a profile similar to that of khellin (a furochromone that directly relaxes smooth muscle) and at a greater potency, suggesting that these compounds have a potential interest for the development of new and more efficient vasodilator drugs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antihypertensive Agents / pharmacology
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Aorta / drug effects
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Coumarins / chemical synthesis*
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Coumarins / pharmacology*
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In Vitro Techniques
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Khellin / pharmacology
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Kinetics
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Muscle, Smooth, Vascular / drug effects
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Norepinephrine / pharmacology
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Potassium Chloride / metabolism
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Rats
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Vasodilator Agents / chemical synthesis*
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Vasodilator Agents / pharmacology*
Substances
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Antihypertensive Agents
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Coumarins
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Vasodilator Agents
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Khellin
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Potassium Chloride
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Norepinephrine