Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance

Bioorg Med Chem Lett. 2002 Feb 25;12(4):571-4. doi: 10.1016/s0960-894x(01)00804-6.

Abstract

The syntheses and SAR studies of various quinazolinone compounds are described for the dual inhibition of Pgp and MRP1 in multidrug resistance.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • Antibiotics, Antineoplastic / antagonists & inhibitors
  • Antibiotics, Antineoplastic / pharmacokinetics
  • Antineoplastic Agents / antagonists & inhibitors
  • Antineoplastic Agents / pharmacokinetics
  • Daunorubicin / antagonists & inhibitors
  • Daunorubicin / pharmacokinetics
  • Doxorubicin / antagonists & inhibitors
  • Doxorubicin / pharmacokinetics
  • Drug Interactions
  • Drug Resistance, Multiple*
  • Humans
  • Inhibitory Concentration 50
  • Quinazolines / chemical synthesis*
  • Quinazolines / chemistry
  • Quinazolines / pharmacology
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Quinazolines
  • Doxorubicin
  • Daunorubicin