Abstract
The mediation of orexin-A-induced hypothermia was investigated. Different doses of orexin-A (140-560 pmol) were administered intracerebroventricularly (i.c.v.) to adult male rats, and the colon temperature was used as an index of the thermoregulatory action. Orexin-A decreased both the basal colon temperature and the lipopolysaccharide-induced fever and exhibited a bell-shaped dose-response curve. I.c.v. pretreatment with neuropeptide Y (NPY) antiserum 24 h before orexin administration significantly decreased the hypothermic effect of orexin-A. These data strengthen the hypothesis that this appetite-regulating peptide might also play a role in thermoregulation, and its hypothermic effect seems to be mediated at least partially by NPY.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Body Temperature / drug effects*
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Body Temperature / physiology
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Body Temperature Regulation / physiology*
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Carrier Proteins / pharmacology*
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Carrier Proteins / therapeutic use
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Colon / physiology
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Dose-Response Relationship, Drug
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Fever / chemically induced
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Fever / drug therapy
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Hypothermia / chemically induced
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Hypothermia / physiopathology*
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Injections, Intraventricular / methods
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Intracellular Signaling Peptides and Proteins*
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Lipopolysaccharides
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Male
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Neuropeptide Y / physiology*
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Neuropeptides / pharmacology*
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Neuropeptides / therapeutic use
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Orexins
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Rats
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Rats, Wistar
Substances
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Carrier Proteins
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Intracellular Signaling Peptides and Proteins
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Lipopolysaccharides
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Neuropeptide Y
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Neuropeptides
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Orexins