Abstract
The eudesmane sesquiterpenoid, verticillatol (1), as well as the lignan, (+)-5'-demethoxyepiexcelsin (2), and a known lignan, (+)-epiexcelsin (3), were isolated from Litsea verticillata Hance. Lignan 2 showed moderate anti-HIV activity with an IC(50) value of 16.4 microg/ml (42.7 microM), while the known lignan 3 was inactive up to a concentration of 20 microg/ml (48.3 microM). Compound 1 demonstrated weak activity with an IC(50) value of 34.5 microg/ml (144.7 microM) while being devoid of cytotoxicity at 20 microg/ml. The structures were elucidated by 1D and 2D NMR spectroscopy, and the absolute configuration of the new sesquiterpenoid was determined by the generation of Mosher esters.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification
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Anti-HIV Agents / pharmacology*
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Cell Line
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology*
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HIV-1 / drug effects
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HIV-1 / pathogenicity
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Lauraceae / chemistry*
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Lignans
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
Substances
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5'-demethoxyepiexcelsin
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Anti-HIV Agents
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Furans
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Lignans
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Sesquiterpenes
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verticillatol