Objective: To observe the distribution and the relationship of 5-Fu in the plasma and the pancreatic juice in post-pancreatoduodenectomy patients after 5-Fu given intravenously.
Methods: After 5-Fu (1.0 g/m(2)) was given intravenously in post-pancreatoduodenectomy patients, blood and pancreatic juice were collected. The 5-Fu concentrations were determined by HPLC and at last the penetration ratio (PR) of 5-Fu was studied with PCNONLIN.
Results: 5-Fu in the plasma penetrated the pancreatic tissue and crossed the blood-pancreatic juice barrier (BPJB) in post-pancreatoduodenectomy patients (PR = 1.01 +/- 0.49). The concentration of 5-Fu in pancreatic juice was much higher than that in plasma.
Conclusions: 5-Fu is suitable for adjuvant chemotherapy of pancreatic adenocarcinoma after pancreatoduodenectomy.