Abstract
Oligosaccharides in which at least one glycosidic oxygen atom is replaced with a sulfur atom can be routinely synthesized and act as competitive inhibitors of various glycoside hydrolases. Recent studies using both X-ray crystallography and other biophysical techniques provide structural insight into binding, recognition, and the catalytic mechanism of action of these enzymes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Carbohydrate Conformation
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Disulfides / chemistry
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Disulfides / pharmacology
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Glycoside Hydrolases / antagonists & inhibitors*
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Oligosaccharides / chemistry*
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Oligosaccharides / pharmacology*
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Protein Binding
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Structure-Activity Relationship
Substances
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Disulfides
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Enzyme Inhibitors
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Oligosaccharides
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Glycoside Hydrolases