Objective: To increase the effect of epilepsy surgery, we use multiple subpial transection (MST) clinically on the basis of experimental study.
Method: We analyzed the seizure type and course of 116 intractable epilepsy patients treated with MST and surgical technique were modified.
Result: 100 patients were followed up for 1 to 5 years. Complete control of seizure was obtained in 62 patients (62%), significant reduction (over 75%) in 20 (20%), reduction (over 50%) in 12 (12%), and no change in 6 (6%). The total effective rate was 94%, and the significant effective rate was 82%. No functional defect was found in any patients.
Conclusion: MST is a effective in surgical treatment of intractable epilepsy and can replace conventional methods. Combined bilateral frontal lobe MST and anterior callosotomy is a good way to treat intractable generalized epilepsy.