[Pharmacokinetical study of safflor yellow on rat acute model of blood stasis syndrome]

Zhong Yao Cai. 2001 Oct;24(10):730-2.
[Article in Chinese]

Abstract

Objective: To study the pharmacokinetical character of safflor yellow in rat acute model of blood stasis syndrome.

Methods: The rat acute model of blood stasis syndrome was made by i.p. adrenalin (0.07 ml/kg) and the stimulation of ice-water. At the time of 5, 10, 30, 60, 120, 180, 320, 480 min, the concentration of safflor yellow in the serum after i.v. safflor yellow (37.08 ml/kg) was determined.

Results: The concentration-time date of safflor yellow in rat acute model of blood stasis syndrome was shown to fit a double-compartment open model, t1/2 alpha = 1.43 min, t1/2 beta = 95.65 min, AUC = 49,632.90 micrograms.min/ml; while the concentration-time data of safflor yellow in normal rat was shown to fit a single-compartment open model, t1/2 alpha = 66.27 min, AUC = 42,267 micrograms.min/ml.

Conclusion: The metabolism of safflor yellow was evidently later in rat acute model of blood stasis syndrome than in normal rat.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Chalcone / analogs & derivatives*
  • Chalcone / pharmacokinetics*
  • Hemorheology
  • Male
  • Medicine, Chinese Traditional
  • Rats
  • Rats, Sprague-Dawley

Substances

  • safflower yellow
  • Chalcone