Formal total synthesis of (+/-)-vindoline by tandem radical cyclization

Org Lett. 2002 Feb 7;4(3):443-5. doi: 10.1021/ol0171618.

Authors

Sheng-ze Zhou¹, Sacha Bommezijn, John A Murphy

Affiliation

¹ Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, G1 IXL Glasgow, Scotland.

PMID: 11820900
DOI: 10.1021/ol0171618

Abstract

A formal total synthesis of (+/-)-vindoline 1 has been achieved featuring the tandem cyclization of radicals produced from the iodoaryl azide 19a.